SC12 Home > SC12 Schedule > SC12 Presentation - Toward Real-Time Modeling of Human Heart Ventricles at Cellular Resolution: Simulation of Drug-Induced Arrhythmias

SCHEDULE: NOV 10-16, 2012

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Toward Real-Time Modeling of Human Heart Ventricles at Cellular Resolution: Simulation of Drug-Induced Arrhythmias

SESSION: ACM Gordon Bell Prize I

EVENT TYPE: ACM Gordon Bell Finalists

TIME: 2:00PM - 2:30PM

SESSION CHAIR: Michael Norman

AUTHOR(S):Arthur A. Mirin, David F. Richards, James N. Glosli, Erik W. Draeger, Bor Chan, Jean-luc Fattebert, William D. Krauss, Tomas Oppelstrup, John Jeremy Rice, John A. Gunnels, Viatcheslav Gurev, Changhoan Kim, John Magerlein, Matthias Reumann, Hui-Fang Wen

ROOM:155-E

ABSTRACT:
We have developed a highly efficient and scalable cardiac electrophysiology simulation capability that supports groundbreaking resolution and detail to elucidate the mechanisms of sudden cardiac death from arrhythmia. We can simulate thousands of heartbeats at a resolution of 0.1 mm, comparable to the size of cardiac cells, thereby enabling scientific inquiry not previously possible. Based on scaling results from the partially deployed Sequoia IBM Blue Gene/Q machine at Lawrence Livermore National Laboratory and planned optimizations, we estimate that by SC12 we will simulate 8-10 heartbeats per minute - a time-to-solution 400-500 times faster than the state-of-the-art. Performance between 8 and 11 PFlop/s on the full 1,572,864 cores is anticipated, representing 4055 percent of peak. The power of the model is demonstrated by illuminating the subtle arrhythmogenic mechanisms of anti-arrhythmic drugs that paradoxically increase arrhythmias in some patient populations.

Chair/Author Details:

Michael Norman (Chair) - University of California, San Diego

Arthur A. Mirin - Lawrence Livermore National Laboratory

David F. Richards - Lawrence Livermore National Laboratory

James N. Glosli - Lawrence Livermore National Laboratory

Erik W. Draeger - Lawrence Livermore National Laboratory

Bor Chan - Lawrence Livermore National Laboratory

Jean-luc Fattebert - Lawrence Livermore National Laboratory

William D. Krauss - Lawrence Livermore National Laboratory

Tomas Oppelstrup - Lawrence Livermore National Laboratory

John Jeremy Rice - IBM T.J. Watson Research Center

John A. Gunnels - IBM T.J. Watson Research Center